Publications

First in-vivo data introducing the concept.

Preliminary-report-of-use-of-a-novel-gel.pdf

 

Material related Publications

Doubly crosslinked hydrogels prepared from pH-responsive vinyl-functionalised hollow particle dispersions , Robert Bird ,  Somjit Tungchaiwattana ,  Tony Freemont and Brian R. Saunders , Soft Matter, 2012,8, 3062-3066
http://dx.doi.org/10.1039/C2SM07366H

Dual pH-triggered physical gels prepared from mixed dispersions of oppositely charged pH-responsive microgels,   James McParlane ,  Damien Dupin ,  Jennifer M. Saunders ,  Sarah Lally ,  Steven P. Armes and Brian R. Saunders  Soft Matter, 2012,8, 6239-6247
http://dx.doi.org/10.1039/C2SM25581B

Doubly crosslinked pH-responsive microgels prepared by particle inter-penetration: swelling and mechanical properties  Ruixue Liu ,  Amir H. Milani ,  Tony J. Freemont and Brian R. Saunders , Soft Matter, 2011,7, 4696-4704
http://dx.doi.org/10.1039/C1SM05216K

Doubly crosslinked microgel–polyelectrolyte complexes: three simple methods to tune and improve gel mechanical properties , Ruixue Liu ,  Jennifer M. Saunders ,  Tony J. Freemont and Brian R. Saunders , Soft Matter, 2012,8, 10932-10940
http://dx.doi.org/10.1039/C2SM26522B

A study of hydrogel composites containing pH-responsive doubly crosslinked microgels , Chonlakan Supasuteekul ,  Amr H. Milani ,  Jennifer M. Saunders ,  Sarah Lally ,  Tony Freemont and Brian R. Saunders , Soft Matter, 2012,8, 7234-7242
http://dx.doi.org/10.1039/C2SM25649E

Injectable Doubly Cross-Linked Microgels for Improving the Mechanical Properties of Degenerated Intervertebral Discs , Amir H. Milani, Anthony J. Freemont, Judith A. Hoyland, Daman J. Adlam, Brian R. Saunders, Biomacromolecules 2012, 13, 2793-2801

Tuning the swelling and mechanical properties of pH-responsive doubly crosslinked microgels using particle composition , Ruixue Liu ,  Amir H. Milani ,  Jennifer. M. Saunders ,  Tony J. Freemont and Brian R. Saunders , Soft Matter, 2011,7, 9297-9306
http://dx.doi.org/10.1039/C1SM05922J

Using osmotic deswelling of microgel particles to control the mechanical properties of pH-responsive hydrogel composites , Sarah Lally ,  Ruixue Liu ,  Chonlakan Supasuteekul ,  Brian R. Saunders and Tony Freemont , J. Mater. Chem., 2011,21, 17719-17728
http://dx.doi.org/10.1039/C1JM13395K

 

 

 

Biology and Clinical related Publications

 

  • New Treatments and Imaging Strategies in Degenerative Disease of the Intervertebral Disks. Lotz JC, Haughton V, Boden SD, An HS, Kang JD, Masuda K, Freemont A, Berven S, Sengupta DK, Tanenbaum L, Maurer P, Ranganathan A, Alavi A, Marinelli NL. Radiology. 2012 Jul;264(1):6-19.
  • The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain. Freemont AJ. Rheumatology (Oxford). 2009 Jan;48(1):5-10.
  • Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies. Richardson SM, Mobasheri A, Freemont AJ, Hoyland JA. Histol Histopathol. 2007 Sep;22(9):1033-41.
  • Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies. Freemont TJ, LeMaitre C, Watkins A, Hoyland JA. Expert Rev Mol Med. 2001 Mar 29;2001:1-10.
  • The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration. Gilbert HT, Hoyland JA, Freemont AJ, Millward-Sadler SJ. Arthritis Res Ther. 2011 Jan 28;13(1):R8.
  • Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs. Le Maitre CL, Frain J, Millward-Sadler J, Fotheringham AP, Freemont AJ, Hoyland JA. Arthritis Rheum. 2009 Feb;60(2):460-9.
  • Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure. Le Maitre CL, Frain J, Fotheringham AP, Freemont AJ, Hoyland JA. Biorheology. 2008;45(5):563-75.
  • End-plate displacement during compression of lumbar vertebra-disc-vertebra segments and the mechanism of failure. Holmes AD, Hukins DW, Freemont AJ. Spine (Phila Pa 1976). 1993 Jan;18(1):128-35.
  • The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Le Maitre CL, Freemont AJ, Hoyland JA. Arthritis Res Ther. 2005;7(4):R732-45.
  • Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc. Tolofari SK, Richardson SM, Freemont AJ, Hoyland JA. Arthritis Res Ther. 2010;12(1):R1.